Potassium Iodide → HCID 66797545, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of benzyl-(6-chloro-quinoxalin-2-yl)-amine (0.250 g, 0.92 mmol, 1 eq), N-Boc-4-pyrazole boronic acid pinacol ester (0.328 g, 1.1 mmol, 1.2 eq), caesium carbonate (1.2 g, 3.71 mmol, 4.03 eq), potassium iodide (0.015 g, 0.09 mmol, 0.1 eq) in 1,4-dioxane (12 mL) was degassed at RT under vacuum and placed under an atmosphere of nitrogen. The process was repeated twice and Fu's catalyst (bis(tri-tert-butylphosphine)-palladium(0)) (0.023 g, 0.046 mmol) was added at RT. The reaction mixture was heated to 100° C. by microwave irradiation for 180 min. The organic mixture was diluted with ethyl acetate (150) and washed with water (20 mL×2) and brine (20 mL). The organic solvent was evaporated under vacuum to give crude product.

Provenance & Evidence