Potassium Iodide → HCID 66797397, compound

Participants

Reaction Conditions

Reaction Steps

N-benzyl-6-chloro-N-methylquinoxalin-2-amine (0.250 g, 0.88 mmol), N-Boc-4-pyrazole boronic acid pinacol ester (0.310 g, 1.05 mmol), caesium carbonate (1.14 g, 3.52 mmol), potassium iodide (0.014 g, 0.088 mmol) were added to 1,4-dioxane (12 mL) at RT. The mixture was degassed under vacuum and was placed under an atmosphere of nitrogen (the process was repeated twice). Fu's catalyst (Bis(tri-tert-butylphosphine) palladium(0)) (0.022 g, 0.04 mmol) was added at RT. The reaction mixture was heated at 100° C. by irradiation for 180 min in a microwave reactor. The organic mixture was diluted with ethyl acetate (150 mL) and washed with water (20 mL×3) followed by brine (20 mL). The organic solvent was distilled under vacuum to afford crude compound.

Provenance & Evidence