Dimethylformamide → 6-Bromo-2-chloroquinoxaline

https://huagongshe.com/reaction/1020733

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	Phosphorus oxychloride	HCID 24813	—
Reactant	6-Bromo-1,2-dihydroquinoxalin-2-one	HCID 12686394	—
Product	6-Bromo-2-chloroquinoxaline	HCID 12686408	—

Reaction Conditions

Temperature	50 °C

Reaction Steps

6-bromoquinoxalin-2(1H)-one (9.0 g, 40 mmol) was dissolved in POCl3 (50 mL) and DMF (2 mL) was added at RT. The mixture was heated at 50° C. for 2 hours. After completion of the reaction it was cooled to RT and was poured slowly into ice cold water. The mixture was stirred for 30 minutes and then filtered to afford crude product.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08716473B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-3e5ac592b50a4e9a9d396461501217df
Source note	uspto-grants-2014_05