1-Methylpiperazine → HCID 66797580, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Trifluoro-methanesulfonic acid 3-((R)-1-tert-butoxycarbonylamino-ethyl)-phenyl ester (0.340 g, 0.921 mmol), 1-methylpiperazine (0.37 g, 3.68 mmol), Pd2(dba)3 (0.042 g, 0.046 mmol), 2-(di-tert-butylphosphino)-biphenyl (0.054 g, 0.184 mmol), and potassium phosphate (0.273 g, 1.29 mmol) in 20 mL of 1,4 dioxane was heated at 80° C. in a sealed tube for 12 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and diluted with ethyl acetate (100 mL) and the washed with water (20 mL). The aqueous layer was extracted with ethyl acetate (2×50 mL), and the combined organic layers were dried over magnesium sulfate and concentrated in vacuo to afford the crude title compound.

Provenance & Evidence