Ammonia → HCID 49819238, compound

Participants

Reaction Steps

To a solution of 4-(2-{Methyl-[3-(4-methyl-piperazin-1-yl)-benzyl]-amino}-quinoxalin-6-yl)-pyrazole-1-carboxylic acid tert-butyl ester (0.110 g, 0.000214 mmol) in 1,4-dioxane (1.5 mL), was added HCl in dioxane (1.0 ml) at room temperature. The mixture was stirred for 1 hour. After completion of the reaction, the reaction mixture was concentrated and washed with diethyl ether (5.0 mL) to afford the crude compound (0.075 g). The compound was basified by ammonia in THF and then further purified by preparative TLC to afford the title compound (0.050 g, 54%). The mobile phase used for the Preparative TLC was DCM:Methanol (9:1).

Provenance & Evidence