Potassium Iodide → HCID 66797422, compound

Participants

Reaction Conditions

Reaction Steps

(6-Bromo-quinoxalin-2-yl)-[(R)-1-(3-methoxy-phenyl)-ethyl]-amine (0.3 g, 0.83 mmol), N-Boc-4-pyrazole boronic acid pinacol ester (0.27 g, 0.92 mmol), caesium carbonate (1.08 g, 3.34 mmol) and potassium iodide (0.014 g, 0.083) were dissolved in 1,4-dioxane (15 mL). The reaction mixture was degassed at RT under vacuum and placed under an atmosphere of nitrogen. The process was repeated twice and Fu's catalyst (Bis(tri-tert-butylphosphine)palladium(0)) (0.021 g, 0.041 mmol) was added at RT. The reaction mixture was heated at 110° C. in a microwave reactor for 180 minutes. The organic mixture was diluted with ethyl acetate (150 mL), washed with water (15 mL×2) and brine (15 mL) and was then dried over Na2SO4. The organic volatiles were evaporated in vacuo to afford crude product.

Provenance & Evidence