Hydrochloric Acid → HCID 66797407, compound

Participants

Reaction Steps

To a mixture of 4-{2-[(R)-1-(3-Methoxy-phenyl)-ethylamino]-quinoxalin-6-yl}-pyrazole-1-carboxylic acid tert-butyl ester and [(R)-1-(3-Methoxy-phenyl)-ethyl]-[6-(1H-pyrazol-4-yl)-quinoxalin-2-yl]-amine (0.12 g of mixture) in 1,4-dioxane was added 4M HCl in 1,4-dioxane at room temperature. The mixture was stirred for 1 hour. After completion of the reaction, the reaction mixture was concentrated in vacuo and was basified using ammonia in THF. The free base was treated with saturated HCl in IPA, followed by trituration in acetone to afford the title compound as the HCl salt (0.020 g).

Provenance & Evidence