Potassium Iodide → HCID 66797158, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (6-Bromo-quinoxalin-2-yl)-[(R)-1-(3-chloro-phenyl)-ethyl]-amine (0.38 g, 1.0 mmol), N-Boc-4-pyrazole boronic acid pinacol ester (0.37 g, 1.2 mmol), caesium carbonate (1.36 g, 4.1 mmol) and potassium iodide (0.017 g, 0.1) in 1,4-dioxane (20 mL) was degassed at RT under vacuum and placed under an atmosphere of nitrogen. The process was repeated twice and Fu's catalyst (Bis(tri-tert-butylphosphine)palladium(0)) (0.053 g, 0.1 mmol) was added at RT. The reaction mixture was heated at 110° C. in a microwave reactor for 180 minutes. The organic mixture was diluted with ethyl acetate (150 mL) and washed with water (20 mL×2) and brine (20 mL). The organic solvent was evaporated in vacuo to afford the crude product.

Provenance & Evidence