HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1020762Generated: November 1, 2026
Pyridine → (R,R)-4-Ethyl-6-[1-(1-phenyl-ethyl)-hexahydro-pyrrolo[3,4-b]pyrrol-5-yl]-pyrimidin-2-ylamine
https://huagongshe.com/reaction/1020762
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Amino-4-chloro-6-ethylpyrimidine | HCID 22324304 | — |
| Reactant | (3aS,6aS)-1-((R)-1-Phenylethyl)octahydropyrrolo[3,4-b]pyrrole | HCID 22646884 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (R,R)-4-Ethyl-6-[1-(1-phenyl-ethyl)-hexahydro-pyrrolo[3,4-b]pyrrol-5-yl]-pyrimidin-2-ylamine | HCID 67096362 | 28% |
Reaction Steps
To a solution of 4-chloro-6-ethyl-pyrimidin-2-ylamine (200 mg, 1.27 mmol) in EtOH (2.4 mL) was added pyridine (210 μL, 2.54 mmol) and 1-(1-phenyl-ethyl)-octahydro-pyrrolo[3,4-b]pyrrole (360 mg, 1.65 mmol). The solution was stirred for 2 h at 90° C. The compound was purified directly with reversed-phase HPLC to yield 115 mg (28%) of the desired compound as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08716475B2 |
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| Source dataset | uspto-grants-2014_05 |
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| ORD ID | ord-70bc1123e2af42c4934862f06509699b |
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| Source note | uspto-grants-2014_05 |
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