HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 150726-52-6
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Bosentan | HCID 104865 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 150726-52-6 | HCID 44387533 | — |
Reaction Steps
Sodium hydroxide (0.44 g) was added to a mixture of bosentan (5 g) in methanol (10 mL), dichloromethane (2.5 mL) and ethyl acetate (40 mL). The reaction mixture was stirred for 3.5 hours at 20° C. to 25° C. and the solid was filtered to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716477B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-7feb390475a2452f9266f708c289d83b |
| Source note | uspto-grants-2014_05 |