反应详情

温度

25 °C

Sodium hydroxide powder (0.43 g) was added to a mixture of bosentan (5 g) in deionized water (20 mL) and the resultant mixture was heated to 55° C. The reaction mixture was stirred for 15 minutes at the same temperature. The reaction mixture was cooled to 25° C. and the mixture was further stirred for 5 hours. The solid obtained was filtered, washed with de-ionized water and dried in air for 12 hours at 55° C. to 60° C. to obtain the title compound.

1. stirringthe mixture was further stirred for 5 hours
2. customThe solid obtained
3. filtrationwas filtered
4. washwashed with de-ionized water
5. customdried in air for 12 hours at 55° C. to 60° C.