反应详情

温度

50 °C

A mixture of bosentan (2 g) in de-ionized water (24 mL) was heated to 50° C. followed by the addition of sodium hydroxide (0.175 g). The reaction mixture was stirred for 3.5 hours at the same temperature and the solid was filtered, washed with de-ionized water (6 mL) and dried under hot air oven at 55° C. to 60° C. to obtain the title compound.

1. filtrationthe solid was filtered
2. washwashed with de-ionized water (6 mL)
3. customdried under hot air oven at 55° C. to 60° C.