HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 6-Chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 6-Chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinamide | HCID 86661728 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 6-Chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinonitrile | HCID 86661729 | — |
Reaction Steps
To a solution of 6-chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinamide (298 mg, 1 mmol) in acetonitrile (20 mL) was added POCl3 (460 mg, 3 mmol) and pyridine (474 mg, 6 mmol). After stirred at r.t for 2 hrs, the mixture was poured into aq. NaHCO3, extracted with EtOAc. The separated organics was dried and concentrated in vacuo to afford 6-chloro-5-cyclopropyl-2-(4-oxopentyloxy)nicotinonitrile. (300 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716478B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-13dd6b6cac3c405b86f1aad990de648d |
| Source note | uspto-grants-2014_05 |