Potassium Carbonate → HCID 66784289, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-fluoro-4-bromophenol (0.576 ml, 5.258 mmol) in DMSO (8 ml) was added K2CO3 (1.451 g, 10.516 mmol) and 2-ethyl-4-nitropyridine [CAS. 101860-96-2] (0.800 g, 5.258 mmol). The reaction mixture was heated at 100° C. for 2 days. Then the reaction mixture was refilled with 2-fluoro-4-bromophenol (0.115 ml) and heated at 100° C. for 6 hours more. After cooling to r.t. the reaction mixture was washed with NaHCO3 (aqueous sat. solution), then extracted with DCM. The organic layer was separated, dried (Na2SO4) evaporated to dryness. The crude product was purified by column chromatography (silica gel; DCM to heptane/DCM from 100/0 to 30/70 as eluent). The desired fractions were collected and concentrated in vacuo to yield intermediate compound D55 (0.985 g, 63%).

Provenance & Evidence