Propionitrile → HCID 53389675, compound

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Reaction Steps

According to AVV A, (Z-3-(4-fluorophenylamino)-but-2-enoic acid benzylester (285.3 mg, 1.0 mmol, 1.0 equiv.) was stirred with Cu(OAc)2 (544.9 mg, 3.0 mmol, 3.0 equiv.) into propionitrile (3.0 ml, 41.9 mmol, 41.9 equiv.) for 24 hours at 120° C. After purification by means of column chromatography (silica gel (50 g), pentane/EtOAc 98:2→70:30→0:100), the product was obtained in the form of a yellow oil (283.0 mg, 0.84 mmol, 84%).

Provenance & Evidence