5,6-dichloro-1,2-dimethylbenzimidazole → HCID 178471416, compound

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Reaction Steps

To 2 (2 g, 1 eq) in 10 mL dichloromethane was added 4 (2.8 g, 1 eq) and stirred in dark for 24 hrs at room temperature. Solvent was evaporated under reduced pressure and the residue was recrystalized from MeOH/diethyl ether to get the white powder as product (4.1 g, 87% yield.) See FIG. 11. 1H NMR: (DMSO) 1.16 (t, 3H), 1.37 (m, 2H), 1.57 (m, 2H), 1.75 (m, 2H), 2.28 (t, 2H), 2.88 (s, 3H), 3.96 (s, 3H), 4.04 (q, 2H), 4.46 (t, 2H), 8.48 (s, 1H), 8.52 (s, 1H). 13C NMR: (DMSO): 10.61, 13.98, 23.90, 25.04, 28.11, 31.98, 33.20, 45.09, 59.58, 114.73, 114.78, 128.76, 128.79, 130.06, 130.91, 154.24, 172.63. ESI-MS (m/z) calcd (found): 357.1 (357.3) for [M]+.

Provenance & Evidence