Stannane, tributyl-1-cyclopenten-1-yl- → HCID 67273815, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-benzenesulfonyl-2-iodo-4-methoxy-1H-pyrrolo[2,3-b]pyridine (1.1 g, 2.65 mmol), tributyl-cyclopent-1-enyl-stannane (1.9 g, 5.31 mmol), and bis(triphenylphosphine)palladium(II) chloride (93 mg) in DMF (10 mL) was heated in a sealed tube to 90° C. for seven hours. The mixture was washed with hexanes (2×10 mL) and the DMF phase was concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel (gradient elution of 10-35% EtOAc/hexanes) to give 0.61 g of 1-benzenesulfonyl-2-cyclopent-1-enyl-4-methoxy-7-azaindole as a yellow solid; MS (m/z) 355 (M+H).

Provenance & Evidence