Cesium fluoride → HCID 67273517, compound

Participants

Reaction Conditions

Reaction Steps

To 500 mg (1.41 mmol) of 2-cyclopent-1-enyl-4-triisopropylsilyloxy-1H-indole (14d step 1) in 5 mL AcCN was added 255 mg (1.68 mmol, 1.2 eq) of CsF and 479 μL (4.23 mmol, 3 eq) 2-bromoethylethyl ether. The reaction was heated at 60° C. overnight then cooled to rt, diluted with CH2Cl2 and filtered through celite and concentrated. The residue was partitioned between ether and H2O, the ether layer was then washed with aqueous NaCl solution, dried (MgSO4), and concentrated under vacuum to yield 282 mg (74%) of 2-cyclopent-1-enyl-4-(2-ethoxy-ethoxy)-1H-indole.

Provenance & Evidence