Ethyl bromoacetate → HCID 67273858, compound

Participants

Reaction Conditions

Reaction Steps

To 300 mg (0.845 mmol) of 2-cyclopent-1-enyl-4-triisopropylsilyloxy-1H-indole (14d step 1) in 3 mL AcCN was added 154 mg (1.01 mmol, 1.2 eq) of CsF and 282 μL (2.54 mmol, 3 eq) ethylbromoacetate and the reaction was stirred at 50° C. overnight. The reaction was diluted with CH2Cl2 and filtered through celite. The CH2Cl2 layer was washed with 2N Na2CO3 solution, H2O, aqueous NaCl solution, dried (Na2SO4), and concentrated in vacuole to yield 239 mg (99%) of (2-cyclopent-1-enyl-1H-indol-4-yloxy)-acetic acid ethyl ester as a dark oil.

Provenance & Evidence