Sodium Hydroxide → HCID 67273211, compound

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Reaction Steps

To 291 mg (0.76 mmol) of the phenylsulfonamide intermediate from step 3 in 50 mL EtOH was added 5 mL 10% NaOH solution. The reaction was heated to reflux overnight and then concentrated. The residue was dissolved in EtOAc, washed with 2N Na2CO3 solution, H2O, aqueous NaCl solution, dried (MgSO4), and concentrated under vacuum to yield 180 mg of 2-cyclopent-1-enyl-4,5-dimethoxy-1H-indole (97%).

Provenance & Evidence