HCID 58371984, compound → HCID 58946426, compound

Participants

Reaction Steps

3-Methoxy-pyrrolidine-1,3-dicarboxylic acid 1-benzyl ester 3-methyl ester 4a in MeOH (2200 mL), was added 14 g of 10% Pd/C (˜50% in water). The reaction mixture was hydrogenated using H2 at ˜55 psi pressure (epen valve) for 1 overnight. The reaction mixture was filtered, dried to give 3-Methoxy-pyrrolidine-3-carboxylic acid methyl ester 11BH 126 g. (overall yield of 70% for 4 steps, no column purification).

Provenance & Evidence