HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1020952Generated: October 31, 2026
Oxonium, triethyl-, hexafluorophosphate(1-) (1:1) → 5-Bromo-thiophene 2-carboximidic acid ethyl ester
https://huagongshe.com/reaction/1020952
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxonium, triethyl-, hexafluorophosphate(1-) (1:1) | HCID 167684 | — |
| Reactant | 5-Bromothiophene-2-carboxamide | HCID 605722 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 5-Bromo-thiophene 2-carboximidic acid ethyl ester | HCID 58371866 | — |
Reaction Steps
The 5-bromo-thiophene 2-carboxylic acid amide (2BW) (7 g, 34.1 mmols) was dissolved in dichloroethane (170 ml). Triethyloxonium hexafluorophosphate (10.16 g, 40.97 mmols) was added and the resulting mixture was refluxed for 1 hr at 90° C. The reaction mixture was concentrated under reduced pressure, and was taken directly to next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08716483B2 |
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| Source dataset | uspto-grants-2014_05 |
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| ORD ID | ord-b62ef39db1c84eb1bdb70fd3c47d91c8 |
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| Source note | uspto-grants-2014_05 |
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