Methylhydrazine → HCID 178486232, compound

HRID 1020953Notes

Reaction equation

HRID 1020953 reaction equation
C(O[C:4]([C:6]1[S:7][C:8]([Br:11])=[CH:9][CH:10]=1)=[NH:5])C.[CH3:12][NH:13][NH2:14]>N1C=CC=CC=1>[CH3:12][NH:13][NH:14][C:4]([C:6]1[S:7][C:8]([Br:11])=[CH:9][CH:10]=1)=[NH:5]

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 583718665-Bromo-thiophene 2-carboximidic acid ethyl ester

Product 1

HCID 178486232HCID 178486232, compoundYield 161.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The 5-bromo-thiophene 2-carboximidic acid ethyl ester (3BW) (13 g, 34.3 mmols) was dissolved in pyridine (100 ml). Methylhydrazine (2.7, 51.45 mmols) was added with stirring and the resulted mixture was allowed to stir overnight. The reaction mixture was concentrated under reduced pressure, and added ether, filtered, washed with ether three times and dried to provide the titled compound (4BW) (13 g).

Workup

  1. stirringto stir overnight
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. additionadded ether
  4. filtrationfiltered
  5. washwashed with ether three times
  6. customdried

Sources & evidence

ORD record
ord-86682fbe9f9d485c8b988ef130f6a9cb
Source dataset
uspto-grants-2014_05
Patent number
US08716483B2

Reaction notes

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