反应详情

The 5-bromo-thiophene 2-carboximidic acid ethyl ester (3BW) (13 g, 34.3 mmols) was dissolved in pyridine (100 ml). Methylhydrazine (2.7, 51.45 mmols) was added with stirring and the resulted mixture was allowed to stir overnight. The reaction mixture was concentrated under reduced pressure, and added ether, filtered, washed with ether three times and dried to provide the titled compound (4BW) (13 g).

1. stirringto stir overnight
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. additionadded ether
4. filtrationfiltered
5. washwashed with ether three times
6. customdried