Pyridine → HCID 178486234, compound

HRID 1020959Notes

Reaction equation

HRID 1020959 reaction equation
[CH3:1][NH:2]N.[Cl:4][C:5]1[CH:14]=[CH:13][C:8]([C:9](=[NH:12])OC)=[CH:7][N:6]=1.[N:15]1C=CC=CC=1>>[Cl:4][C:5]1[CH:14]=[CH:13][C:8]([C:9](=[NH:15])[NH:12][NH:2][CH3:1])=[CH:7][N:6]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 6061MethylhydrazineHCID 86762380Methyl 6-chloronicotinimidate

Product 1

HCID 178486234HCID 178486234, compound

Procedure

Methyl hydrazine (750 mg, 16.30 mmol) was added to a solution of Methyl 6-chloronicotinimidate (1BX) (2.6 g, 15.29 mmol) in Pyridine (10 ml) at room temperature, then stirred for 1 hour. The solvent was evaporated, and residual solid triturated with cold Ether (2×10 ml) yielding title product 2BX as a yellow powder (2.4 g, 85%) MS (MH, 185)

Workup

  1. customThe solvent was evaporated
  2. customresidual solid triturated with cold Ether (2×10 ml)

Sources & evidence

ORD record
ord-2b9a007d577b428cabec20b5c5aff091
Source dataset
uspto-grants-2014_05
Patent number
US08716483B2

Reaction notes

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