Potassium Carbonate → HCID 58371919, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,5-dibromothiophene (1.5 g, 6.2 mmol), pyridazin-3(2H)-one (0.4 g, 4.1 mmol), copper(I) iodide (0.24 g, 1.2 mmol), potassium carbonate (1.7 g, 12.4 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (0.2 mL, 1.2 mmol) and toluene (15 mL) was degassed for 15 minutes and then heated in a sealed tube at 110° C. for 18 hours. Cooled to room temperature, filtered through celite and washed with EtOAc. The filterate was washed with water (100 mL×2). The organic layer was dried over Na2SO4, filtered and concentrated give the desired product 2BZ (0.9 g, 90%). The residue was purified on silica gel eluting with 80% EtOAc/hexane to give the desired product 2BZ (0.7 g, 67%).

Provenance & Evidence