反应详情

温度

80 °C

Tetrakis(triphenylphosphine)palladium (36 mg) and sodium carbonate (330 mg) were added to a mixture of 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine (300 mg), (3-bromophenyl)methanol (233 mg), DME (6 ml), and water (3 ml), followed by stirring at 80° C. overnight, and then the reaction mixture was concentrated under reduced pressure. Water and CHCl3 were added to the obtained residue, and the organic layer was dried over MgSO4, and then concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (EtOAc/hexane/CHCl3) to obtain [4′-(morpholin-4-yl)biphenyl-3-yl]methanol (242 mg).

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. additionWater and CHCl3 were added to the obtained residue
3. dry with materialthe organic layer was dried over MgSO4
4. concentrationconcentrated under reduced pressure
5. customThe obtained residue was purified by silica gel column chromatography (EtOAc/hexane/CHCl3)