Morpholine → 4-(5-Bromo-1,3-thiazol-2-yl)morpholine

HRID 1021233Notes

Reaction equation

HRID 1021233 reaction equation
Br[C:2]1[S:3][C:4]([Br:7])=[CH:5][N:6]=1.[NH:8]1[CH2:13][CH2:12][O:11][CH2:10][CH2:9]1>O>[Br:7][C:4]1[S:3][C:2]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:6][CH:5]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 3123942,5-Dibromothiazole

Product 1

HCID 457875514-(5-Bromo-1,3-thiazol-2-yl)morpholine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

2,5-Dibromo-1,3-thiazole (500 mg) was mixed with morpholine (2 ml), followed by stirring at 60° C. for 5 hours. Water was added to the reaction mixture, followed by stirring for 1 hour, and the resulting insoluble matter was collected by filtration, followed by washing with water, to obtain 4-(5-bromo-1,3-thiazol-2-yl)morpholine (475 mg).

Workup

  1. stirringby stirring for 1 hour
  2. filtrationthe resulting insoluble matter was collected by filtration
  3. washby washing with water

Sources & evidence

ORD record
ord-2cad20cf8a374898baee64ad2edc7228
Source dataset
uspto-grants-2014_05
Patent number
US08716470B2

Reaction notes

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