反应详情

温度

90 °C

2-Fluoro-3-methylbenzoic acid (8.0 g) was mixed with EtOH (100 ml), and concentrated sulfuric acid was added thereto, followed by stirring at 90° C. overnight. The reaction mixture was concentrated under reduced pressure, and EtOAc and water were then added thereto. The organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution, then dried over Na2SO4, and concentrated under reduced pressure to obtain ethyl 2-fluoro-3-methylbenzoate (7.84 g).

1. additionwas added
2. concentrationThe reaction mixture was concentrated under reduced pressure, and EtOAc and water
3. additionwere then added
4. washThe organic layer was washed with a saturated aqueous sodium hydrogen carbonate solution
5. dry with materialdried over Na2SO4
6. concentrationconcentrated under reduced pressure