HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 4-(5-Bromo-4-methylpyrimidin-2-yl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 4-(4-Methylpyrimidin-2-yl)morpholine | HCID 58742240 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 4-(5-Bromo-4-methylpyrimidin-2-yl)morpholine | HCID 68308931 | 86.1% |
Reaction Steps
4-(4-Methylpyrimidin-2-yl)morpholine (300 mg) was mixed with dichloromethane (4 ml), and N-bromosuccinimide (357 mg) was added thereto at 0° C., followed by stirring at room temperature for 1 hour. Hexane was added to the reaction mixture, followed by purification by silica gel column chromatography (EtOAc/hexane), to obtain 4-(5-bromo-4-methylpyrimidin-2-yl)morpholine (372 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716470B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-aa907ad46ea144e7a1bba7533901da86 |
| Source note | uspto-grants-2014_05 |