Ethanol hydrochloride → HCID 178493702, compound

HRID 1021321Notes

Reaction equation

HRID 1021321 reaction equation
[ClH:1].CCO.[C:5]([NH:8][C:9](=[O:37])[O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:25]=[N:26][C:27]([N:30]4[CH2:33][CH:32]([O:34][CH3:35])[CH2:31]4)=[N:28][CH:29]=3)[CH2:20][CH2:19]2)[C:13]=1[F:36])(=[NH:7])[NH2:6]>CCO>[ClH:1].[ClH:1].[ClH:1].[C:5]([NH:8][C:9](=[O:37])[O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([N:18]2[CH2:23][CH2:22][N:21]([C:24]3[CH:25]=[N:26][C:27]([N:30]4[CH2:33][CH:32]([O:34][CH3:35])[CH2:31]4)=[N:28][CH:29]=3)[CH2:20][CH2:19]2)[C:13]=1[F:36])(=[NH:6])[NH2:7]

Participants

4

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 178493701HCID 178493701, compound

Product 1

HCID 178493702HCID 178493702, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 4 M hydrogen chloride/EtOH solution (1.5 ml) was added to a mixture of 2-fluoro-3-{4-[2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]piperazin-1-yl}benzyl carbamimidoylcarbamate (285 mg) and EtOH (5 ml), followed by stirring at room temperature. The precipitated yellow solid was collected by filtration and washed with EtOH. The obtained solid was dried at 40° C. under reduced pressure to obtain 2-fluoro-3-{4-[2-(3-methoxyazetidin-1-yl)pyrimidin-5-yl]piperazin-1-yl}benzyl carbamimidoylcarbamate trihydrochloride (330 mg).

Workup

  1. filtrationThe precipitated yellow solid was collected by filtration
  2. washwashed with EtOH
  3. customThe obtained solid was dried at 40° C. under reduced pressure

Sources & evidence

ORD record
ord-3aa1c532ecd6468891abf69336d9b254
Source dataset
uspto-grants-2014_05
Patent number
US08716470B2

Reaction notes

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