HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1021356Generated: November 1, 2026
Tetrahydrofuran → methyl 7-fluoro-3,4-dihydro-2H-chromene-4-carboxylate
https://huagongshe.com/reaction/1021356
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 7-fluoro-3,4-dihydro-2H-chromene-4-carboxylic acid | HCID 67080233 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | methyl 7-fluoro-3,4-dihydro-2H-chromene-4-carboxylate | HCID 67080260 | 98.7% |
Reaction Steps
7-Fluoro-3,4-dihydro-2H-chromene-4-carboxylic acid (346 mg, 1.76 mmol) was diluted with (THF) 2 mL, methanol (2 mL) and 4 drops of sulfuric acid. The reaction was heated at 55° C. and stirred for 12 hours. The reaction was cooled to ambient temperature, diluted with ethyl acetate and saturated sodium bicarbonate. The layers were separated and the organic layer was dried over MgSO4, filtered and concentrated to yield the title compound (366 mg, 98.7% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08716498B2 |
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| Source dataset | uspto-grants-2014_05 |
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| ORD ID | ord-187493ba19ab4cf1acb706d50924ce69 |
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| Source note | uspto-grants-2014_05 |
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