HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(6-Cyano-4-(methoxycarbonyl)-chroman-7-yloxy)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Methyl 7-(4-(tert-butoxycarbonyl)phenoxy)-6-cyanochroman-4-carboxylate | HCID 67080240 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(6-Cyano-4-(methoxycarbonyl)-chroman-7-yloxy)benzoic acid | HCID 46221108 | 69.5% |
Reaction Steps
Methyl 7-(4-(tert-butoxycarbonyl)phenoxy)-6-cyanochroman-4-carboxylate (400 mg, 0.977 mmol) was diluted with CH2Cl2 followed by the addition of TFA (1 mL). After stirring for 2 hours, the reaction was concentrated to yield the title compound (240 mg, 69.5% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08716498B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-62e4be9308324379affa47fc94d64b06 |
| Source note | uspto-grants-2014_05 |