反应详情

To a solution of ethyl 6-chloro-7-(4-(3-phenylcyclobutylcarbamoyl)phenoxy)chroman-4-carboxylate (0.086 g, 0.17 mmol) in 3:1 THF/ethanol (4 ml) was added 1M sodium hydroxide (0.36 ml, 0.36 mmol), and the reaction was stirred overnight. The reaction was concentrated, taken up in water, acidified with 1M hydrochloric acid, and extracted twice with EtOAc. The combined organic layers were washed with saturated sodium chloride, dried over Na2SO4, filtered, and concentrated to yield 67 mg of the title compound (82% yield).

1. concentrationThe reaction was concentrated
2. extractionextracted twice with EtOAc
3. washThe combined organic layers were washed with saturated sodium chloride
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated