tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate → (3S)-tert-Butyl 4-(6-Aminopyridin-3-yl)-3-methylpiperazine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate	HCID 11737525	—
Reactant	tert-butyl (3S)-3-methyl-4-(6-nitropyridin-3-yl)piperazine-1-carboxylate	HCID 86683728	—
Product	(3S)-tert-Butyl 4-(6-Aminopyridin-3-yl)-3-methylpiperazine-1-carboxylate	HCID 86683730	96%

Following the procedures as described for compound 101h, hydrogenation of 130a (5.8 g) afforded 130b as a brown solid (4.9 g, 96%). LCMS: [M+H]+ 293