反应详情

A 100-mL Parr hydrogenation bottle was purged with nitrogen and charged with 206b (1.07 g, 3.6 mmol), 10% palladium on carbon (50% wet, 0.30 g), and methanol (60 mL). The bottle was evacuated, charged with hydrogen gas to a pressure of 25 psi, and shaken for 2 h on a Parr hydrogenation apparatus. The hydrogen was then evacuated and nitrogen charged to the bottle. The catalyst was removed by filtration through a pad of CELITE® and the filtrate was concentrated under reduced pressure to afford 206c (0.95 g, 99%). MS-ESI: [M+H]+ 266.

1. customA 100-mL Parr hydrogenation bottle was purged with nitrogen
2. customThe bottle was evacuated
3. additioncharged with hydrogen gas to a pressure of 25 psi
4. customThe hydrogen was then evacuated
5. additionnitrogen charged to the bottle
6. customThe catalyst was removed by filtration through a pad of CELITE®
7. concentrationthe filtrate was concentrated under reduced pressure