反应详情

温度

80 °C

A mixture of (S)-tert-butyl 3-methylpiperazine-1-carboxylate (6.0 g, 30 mmol) and 2,5-dibromopyrazine (14.1 g, 60 mmol) was stirred at 80° C. for 15 h. It was then cooled to room temperature and purified by silica-gel column chromatography eluting with petroleum ether/ethyl acetate (10:1 to 2:1) to afford 230a as a yellow solid (1.14 g, 19%). MS: [M+H]+ 359.1.

1. temperatureIt was then cooled to room temperature
2. custompurified by silica-gel column chromatography
3. washeluting with petroleum ether/ethyl acetate (10:1 to 2:1)