反应详情

温度

60 °C

25.7 g of thionylchloride are added at a temperature of 0-10° C. within 40 minutes to a suspension of 12.5 g of 4-amino-1-methoxy-piperidine-4-carboxylic acid in 100 ml of methanol. The reaction mixture is then heated up to 60° C. for 48 h. After cooling to 20° C., the solids are filtered and the filtrate is evaporated to give 13.2 g of 4-amino-1-methoxy-piperidine-4-carboxylic acid methyl ester hydrochloride as brown cristalline solid.

1. temperatureAfter cooling to 20° C.
2. filtrationthe solids are filtered
3. customthe filtrate is evaporated