HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → (5-Cyclopropyl-2,4-dimethyl-phenyl)-acetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | (5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid | HCID 59614593 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (5-Cyclopropyl-2,4-dimethyl-phenyl)-acetyl chloride | HCID 59614607 | — |
Reaction Steps
2.3 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid in 20 ml of dichloromethane are treated with 2.1 g of oxalyl chloride and a catalytic amount of dimethylformamide. The reaction mixture is stirred at room temperature for 2 hours. The solvent is removed in vacuo and the crude residue of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetyl chloride (2.5 g) is used for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722578B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-cd3381abb539478ab98ae976572fd311 |
| Source note | uspto-grants-2014_05 |