Ammonia → HCID 68662367, compound

Participants

Reaction Steps

A mixture of 300 mg of 2,6,8-trichloro-4-phenylquinazoline (compound No. II-5), 30 g of an aqueous 28% ammonia solution and 6 ml of acetonitrile was reacted in a pressure-resistant reaction vessel at 105° C. for 1.5 hours. The resulting reaction solution was cooled and then poured into 100 ml of water. The mixture was extracted with 60 ml of ethyl acetate and the resultant extract was concentrated. The resulting residue was purified by silica gel column chromatography (chloroform) to obtain 230 mg of the titled compound. Mp. 212.7° C. 1H NMR (CDCl3): 5.56 (2H, br. s), 7.54-7.60 (3H, m), 7.63-7.68 (2H, m), 7.74 (1H, d, J=2.3 Hz), 7.79 (1H, d, J=2.3 Hz).

Provenance & Evidence