1-(2-Fluorophenyl)piperazine → HCID 72548960, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-chloro-1-methyl-1,5-dihydro-pyrrolo[3,2-c]pyridine-4-one (Intermediate G) (17 mg, 0.09 mmol) and 1-(2-fluorophenyl)piperazine (140 mg, 0.77 mmol) was heated at 140° C. in a sealed tube overnight. Flash chromatography (20/1 methylene chloride/methanol) afforded 6-[4-(2-fluoro-phenyl)-piperazin-1-yl]-1-methyl-1,5-dihydro-pyrrolo[3,2-c]pyridin-4-one (20 mg, 65.8%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.1 (d, J=4.77 Hz, 4H) 3.2-3.3 (m, 4H) 3.6 (s, 3H) 5.8 (s, 1H) 6.3 (d, J=3.01 Hz, 1H) 6.9 (d, J=3.01 Hz, 1H) 7.0-7.0 (m, 1H) 7.1-7.2 (m, 3H) 10.6 (s, 1H). LC-MS calcd. for C18H20FN4O [(M+H)+] 327, obsd. 327.1.

Provenance & Evidence