Hydrochloric Acid → HCID 136344413, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2,4-dichloro-7-cyclopropyl-7H-pyrrolo[2,3-d]pyrimidine (68 mg, 298 μmol) in a 2N aqueous potassium hydroxide solution (1.67 ml, 3.34 mmol) was heated to 100° C. overnight. At this time, the reaction was cooled to room temperature. The reaction was diluted with water (−50 mL) and then neutralized by the addition of a 2N aqueous hydrochloric acid solution. The product was extracted into a 10% methanol/methylene chloride solution (3×25 mL), dried over sodium sulfate, filtered and concentrated in vacuo to afford 2-chloro-7-cyclopropyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one as a light yellow solid (59.9 mg, 95.8%). 1H NMR (300 MHz, DMSO-d6) δ ppm 0.78-1.17 (m, 4H) 3.50 (s, 1H) 6.42 (d, J=3.39 Hz, 1H) 7.07 (br. s., 1H) 12.87 (br. s., 1H). LC-MS calcd. for C9H9ClN3O [(M+H)+] 210, obsd. 209.9.

Provenance & Evidence