Acetic Anhydride → HCID 86691699, compound

Participants

Reaction Steps

To a cooled solution of (3S,4R,5R,6S)-6-[4-bromo-3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-phenyl]-tetrahydro-pyran-2,3,4,5-tetraol (4.7 g, 9.9 mmol) in pyridine (20 ml) was added acetic anhydride (8.1 g, 79.5 mmol) at 0° C. After complete addition reaction mixture was stirred at room temperature for 2 h. Pyridine was evaporated under reduced pressure. The resulting residue was taken in ethyl acetate and washed with aqueous 1 N sodium bisulfate solution followed by brine, dried over sodium sulfate, concentrated to give 3.5 g of acetic acid (3S,4R,5S,6S)-3,4,5-triacetoxy-6-[4-bromo-3-(2,3-dihydro-benzo[1,4]dioxin-6-ylmethyl)-phenyl]-tetrahydro-pyran-2-yl ester.

Provenance & Evidence