HuagongsheHuagongshe Chemistry Print Report · For research reference only
Veratrylamine → HCID 67496265, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Veratrylamine | HCID 79832 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | HCID 67496094 | HCID 67496094 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67496265 | HCID 67496265 | 80.2% |
Reaction Steps
A mixture of 1 g of the compound obtained in Step 1.1, 0.646 g of veratrylamine, 1.152 g of DIEA and 1.69 g of HBTU in 50 ml of DMF is stirred for 2 days at room temperature. The reaction medium is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/EtOAc mixture from (100/0, v/v) to (80/20, v/v) to give 1.2 g of a solid, which is used without purification in the following step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722659B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-8ac093f5953740af86c1fa03d2722a97 |
| Source note | uspto-grants-2014_05 |