Hydrochloric Acid → HCID 67496615, compound

Participants

Reaction Steps

A mixture of 0.235 g of 2-amino-5-(benzyloxy)-N-(3,4-dimethoxybenzyl)benzamide, 0.090 g of tetrahydro-4H-thiopyran-4-one and 0.78 g of sodium triacetoxyborohydride in 0.5 ml of acetic acid is irradiated in a microwave field for 5 minutes at 130° C. 1N HCl is added and the mixture is extracted with EtOAc. The organic phase is dried over MgSO4 and filtered, and the filtrate is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a heptane/EtOAc mixture from (90/10, v/v) to (20/80, v/v) to give 0.2 g of the expected product.

Provenance & Evidence