Ammonium formate → 6-amino-3-(3,4-dimethoxybenzyl)-1-(tetrahydro-2H-pyran-4-yl)quinazoline-2,4(1H,3H)-dione

Participants

Reaction Steps

A mixture of 1 g of the compound obtained in Step 6.3, 0.36 g of ammonium formate and 0.24 g of Pd/C (10%) in 10 ml of EtOH purged beforehand with nitrogen is irradiated in a microwave field for 10 minutes at 80° C. The resulting mixture is filtered and the filtrate is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with an EtOAc/DCM mixture from (0/100, v/v) to (100/0, v/v) to give the expected product.

Provenance & Evidence