Tributylphosphine → HCID 66732267, compound

Participants

Reaction Steps

A mixture of 0.2 g of 6-bromo-3-(3,4-dimethoxybenzyl)-1-(tetrahydro-2H-pyran-4-yl)-quinazoline-2,4(1H,3H)-dione, 0.096 g of 3-benzyloxyazetidine, 0.006 g of palladium acetate, 0.055 g of sodium tert-butoxide and 0.01 ml of tributylphosphine in 4 ml of DMF is stirred for 4 days at room temperature. The reaction mixture is filtered and evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/EtOAc mixture from (100/0, v/v) to (20/80, v/v) to give 0.041 g of the expected product.

Provenance & Evidence