Ammonium formate → 3-(3,4-dimethoxybenzyl)-6-(3-hydroxyazetidin-1-yl)-1-(tetrahydro-2H-pyran-4-yl)-quinazoline-2,4(1H,3H)-dione

Participants

Reaction Steps

A mixture of 0.04 g of the compound obtained in Step 10.1, 0.007 g of ammonium formate and 0.008 g of Pd/C (10%) in 7.2 ml of EtOH is irradiated in a microwave field for 1 hour at 120° C. The reaction mixture is filtered and evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/MeOH mixture from (100/0, v/v) to (95/5, v/v) to give 0.017 g of the expected product.

Provenance & Evidence