HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → HCID 49764533, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6-(aminomethyl)-3-(3,4-dimethoxybenzyl)-1-(tetrahydro-2H-pyran-4-yl)quinazoline-2,4(1H,3H)-dione | HCID 66732924 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 49764533 | HCID 49764533 | 77.2% |
Reaction Steps
0.066 g of acetic anhydride is added at 0° C. to a solution of 0.23 g of the compound obtained in Step 12.2 and 0.11 g of Et3N in 5 ml of DCM. The mixture is stirred at room temperature for 2 hours. The organic phase is washed with saturated NH4Cl solution, filtered and evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/MeOH mixture from (99/1, v/v) to (95/5, v/v) to give 0.195 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08722659B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-70aaac32ec6041c8bac20cae1e36da57 |
| Source note | uspto-grants-2014_05 |