Potassium cyanate → HCID 67495309, compound

Participants

Reaction Steps

A mixture of 0.1 g of 6-(aminomethyl)-3-(3,4-dimethoxybenzyl)-1-(tetrahydro-2H-pyran-4-yl)quinazoline-2,4(1H,3H)-dione and 0.025 g of potassium cyanate in 2 ml of acetic acid is irradiated in a microwave field for 4 minutes at 120° C. The resulting mixture is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/MeOH mixture from (100/0, v/v) to (93/7, v/v) to give 0.06 g of the expected product.

Provenance & Evidence