反应详情

温度

-78 °C

A stream of ozone is passed for 10 minutes through a solution of 1.4 g of the compound obtained in Step 14.1 in 100 ml of DCM cooled to −78° C. The reaction medium is degassed with nitrogen, 40 ml of dimethyl sulfide are added and the resulting mixture is stirred overnight at room temperature. The reaction medium is evaporated under reduced pressure. The residue is chromatographed on silica gel, eluting with a DCM/EtOAc mixture from (100/0, v/v) to (60/40, v/v) to give 0.58 g of the expected product.

1. customThe reaction medium is degassed with nitrogen, 40 ml of dimethyl sulfide
2. additionare added
3. customThe reaction medium is evaporated under reduced pressure
4. customThe residue is chromatographed on silica gel
5. washeluting with a DCM/EtOAc mixture from (100/0